温通甘皮 (WenTongGanPi) 可以通过改善肠道屏障来缓解腹占主导地位的刺激性肠综合征
Yaoguang Li1, Yangyang Chen2, Zhengyue Liao3
1College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611103, China.
Journal of ethnopharmacology
|July 16, 2024
概括
温通甘 (WenTongGanPi Decoction,简称WTGPD) 通过改善肠道屏障和肠道微生物群,有效治疗腹占主导地位的刺激性肠综合征 (IBS-D). 这种传统中医药抑制了MAPK信号通路,为IBS-D.提供了一种新的治疗方法.
科学领域:
- 综合医学是一个整体的医学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 温通甘皮 (WenTongGanPi Decoction,简称WTGPD) 是源自富阳学派的一种传统中医 (TCM) 实践,强调阳气平衡.
- 它在临床上用于肝气停滞和缺陷,这些情况通常与腹占主导地位的刺激性肠综合征 (IBS-D) 相关.
- 通过WTGPD对IBS-D产生治疗作用的确切机制尚未完全理解.
研究的目的:
- 为了研究WTGPD在IBS-D.小鼠模型上的治疗效果.
- 阐明 WTGPD 在治疗 IBS-D. 的基础药理机制.
主要方法:
- 通过使用慢性压力和 sennae folium建立了IBS-D大鼠模型.
- 评估WTGPD的有效性是通过体重,便中的水含量和腹部戒断反应.
- 分析了肠道透性,结肠结构,蛋白质表达 (紧密结节,MAPK通路),肠道微生物群组成和代谢物.
- 使用UPLC-Q-TOF-MS.MS进行了WTGPD的组件分析.
主要成果:
- 在IBS-D大鼠中,WTGPD显著缓解了腹和腹痛.
- 它通过增强结肠结构和紧密结节蛋白表达来改善肠道屏障功能.
- WTGPD调节了MAPK信号通路 (减少p-p38,p-ERK,p-JNK) 并改变了肠道微生物群的多样性,增加了酸的产生.
- 关键化合物,如关素,腺素和素被确定为可能参与MAPK通路调节.
结论:
- WTGPD显示了IBS-D的显著治疗潜力.
- 该机制涉及抑制MAPK信号通路和改善肠道失生症.
- WTGPD改善了肠道屏障功能,并调节了肠道微生物群,为IBS-D治疗提供了全面的方法.
相关概念视频
Drugs for Treatment of Diarrhea-Predominant IBS
156
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
156
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
203
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
203
Drugs for Treatment of Constipation-Predominant IBS
152
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
152
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
188
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
188
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Irritable Bowel Syndrome I: Introduction
264
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
264


