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Updated: Jun 21, 2025

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
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Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

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经过50年的肝脏清除模型,我们应该从这里走到哪里? 对生理学基础的药理动力学建模的改进和影响

K Sandy Pang1, Weijia Ivy Lu2, Gerard J Mulder2

  • 1Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada (K.S.P., W.I.L.) and Department of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands (G.J.M.) ks.pang@utoronto.ca.

Drug metabolism and disposition: the biological fate of chemicals
|July 16, 2024
PubMed
概括

迷你平行管模型 (miniPTM) 比精心的模型 (WSM) 更好地预测肝脏药物清除. 这个模型模仿了肝脏的血液流动,改善了药物代谢和清除的体内预测.

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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