Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.3K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.1K
Synteny and Evolution02:31

Synteny and Evolution

3.2K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.2K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

3.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Haplotype-aware long-read error correction.

Algorithms for molecular biology : AMB·2026
Same author

Cannabidiol in Digital Fatigue: Neuroadaptive Mechanisms and Therapeutic Perspectives on Chronic Screen Exposure.

CNS & neurological disorders drug targets·2026
Same author

Holistic simulation of iron-sulfur cluster electronic and physical structures with hybrid density functional approximation reduced density matrix functional theory.

The Journal of chemical physics·2026
Same author

Synergistic Interplay Between Probiotic-coated Nanoparticles and Antimicrobial Peptides in Food Biochemistry: Engineering Bioremediation Agents for Heavy Metal Detoxification.

Recent advances in food, nutrition & agriculture·2026
Same author

Immunomodulatory Nanocarriers in Multiple Sclerosis: Dual Targeting of Microglia and Mitochondria for Precision Neurotherapy.

Anti-inflammatory & anti-allergy agents in medicinal chemistry·2026
Same author

Polythiophene Nanocomposites as Smart and Sustainable Materials: Advancements in Energy, Environmental, and Biomedical Technologies.

Anti-inflammatory & anti-allergy agents in medicinal chemistry·2026
Same journal

A unified analysis of cell type- and trajectory-associated pathways in single-cell data using Phoenix.

Genome research·2026
Same journal

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin.

Genome research·2026
Same journal

Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.

Genome research·2026
Same journal

Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD.

Genome research·2026
Same journal

Spatially resolved profiling of steroid nuclear receptors reveals a role for the disordered N-terminal domains in genome targeting and AP-1 interaction.

Genome research·2026
Same journal

Flexible and scalable inference of spatially varying correlation in spatial transcriptomics with spCorr.

Genome research·2026
查看所有相关文章

相关实验视频

Updated: Jun 21, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.1K

哈普洛型感知序列对齐到泛型组图的图表.

Ghanshyam Chandra1, Daniel Gibney2, Chirag Jain3

  • 1Department of Computational and Data Sciences, Indian Institute of Science, Bangalore Karnataka 560012, India.

Genome research
|July 16, 2024
PubMed
概括
此摘要是机器生成的。

我们开发了新的算法,用于对基因组图中的序列对齐,并结合了重组惩罚来提高准确性. 这种方法提高了读取映射与已知的单元类型的一致性,减少了复杂的基因组区域中的虚假对齐.

更多相关视频

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

7.1K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.4K

相关实验视频

Last Updated: Jun 21, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.1K
Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

7.1K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.4K

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 由哈普洛型解析组件构建的泛氏名图形对于准确的读取映射至关重要.
  • 目前的对齐方法忽视了单元型路径,导致错误的对齐和基因型错误.

研究的目的:

  • 开发用于序列-图形对齐和链接的新算法,这些算法可以解释单元型信息.
  • 引入重组惩罚,以惩罚在对齐过程中不太可能发生的单 haplotype 开关.

主要方法:

  • 开发了一种具有哈普罗型意识的序列对图对齐算法,并处以重组惩罚.
  • 制定了一种对哈普罗类型有意识的链接算法,以改进选.
  • 根据强指数时间假说 (SETH) 证明了对齐和链接问题的理论下限.

主要成果:

  • 实现了在O{\displaystyle O{\text{QE}}}时间内运行的对齐算法,其下限已被证明是近于最佳的.
  • 开发了一个链接算法运行在O(N^2) 时间的预处理后,也证明了近最佳的下界.
  • 使用Minichain对齐器对人类MHC数据进行基准真理重组的改进一致性.

结论:

  • 具有哈普洛型意识的对齐和链接算法显著提高了 pangenome 图形中的读取映射准确性.
  • 拟议的重组惩罚有效地将序列变异模型作为参考单元类型的马赛克.
  • 这些进展对于准确的基因型定型和理解基因组多样性至关重要.