第一阶段胰岛素分泌的替代测量与参考方法静脉注射葡萄糖耐受性测试和高血糖:系统性审查和元分析
Rebecka Renklint1, Youssef Chninou2, Martin Heni3,4,5
1Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden rebeckarenklint@hotmail.com.
BMJ open diabetes research & care
|July 16, 2024
概括
口服葡萄糖耐受性测试 (OGTT) 准确地测量第一阶段胰岛素分泌,使其适合流行病学研究. 恒温模式评估 (HOMA) -β提供了中等的相关性,但没有专门评估第一阶段胰岛素分泌.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 诊断的准确性 诊断的准确性
背景情况:
- 评估胰岛素分泌对于了解葡萄糖代谢和诊断糖尿病至关重要.
- 像高血糖 (HGC) 和静脉输血葡萄糖耐受性测试 (IVGTT) 这样的黄金标准方法是侵入性的,对于大规模研究来说是不切实际的.
- 替代措施为评估胰岛素分泌提供了一个不那么侵入性的替代方案.
研究的目的:
- 系统地审查和评估第一阶段胰岛素分泌的替代措施的诊断准确性.
- 将从禁食样本和口服葡萄糖耐受性测试 (OGTT) 获得的替代措施与黄金标准方法进行比较.
- 确定在流行病学研究中使用的最可靠的替代措施.
主要方法:
- 在PubMed,Cochrane Central和Web of Science数据库中进行系统搜索,截至2021年6月.
- 包括使用黄金标准 (HGC或IVGTT) 和代用方法测量第一阶段胰岛素分泌的研究.
- 使用QUADAS-2和随机效应元分析进行质量评估以确定相关性.
主要成果:
- 包括33篇涉及5362名参与者的文章.
- 恒温模式评估 (HOMA) -beta和胰岛素原性指数30 (IGI) 是最常被研究的替代措施.
- 来自OGTT的测量,特别是Kadowaki (相关性0.67) 和Stumvoll的第一阶段分泌 (相关性0.65),与黄金标准方法的相关性最高.
结论:
- 在OGTT的前30分钟内获得的替代测量有效捕获第一阶段胰岛素分泌.
- 这些OGTT衍生措施被推用于流行病学研究,因为它们的准确性和实用性.
- 虽然HOMA-β显示了中等的相关性,但它并不特定于第一阶段胰岛素分泌.
关键词:
胰岛素分泌 胰岛素分泌相关概念视频
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