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数字技术的性能测量结核病药物坚持:一个系统的审查

Miranda Zary¹, Mona Salaheldin Mohamed¹, Cedric Kafie¹

¹McGill International Tuberculosis Centre, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

BMJ global health

|July 16, 2024

概括

数字坚持技术 (DAT) 在测量结核病 (TB) 药物坚持方面显示出可变的性能. 需要进一步的研究来了解DAT在现实环境中的有效性.

科学领域:

公共卫生公共卫生
传染性疾病传染性疾病
卫生技术评估卫生技术评估

背景情况:

数字坚持技术 (DAT) 为结核病 (TB) 治疗提供以人为本的支持.
在测量药物坚持方面,DAT性能的估计有很大的差异.

研究的目的:

系统地审查和综合测量结核病药物坚持性的DATs的性能.
确定证据缺口和未来对DAT有效性的研究领域.

主要方法:

从五个数据库中对已发表的文献和预印件进行系统审查 (2000年1月至2023年4月).
包括报告DAT的定量性能数据与至少20名参与者的参考标准相比的研究.
提取的研究特征和性能结果,包括敏感性和特异性.

主要成果:

13项研究符合纳入标准,调查了各种DAT,如药物袖子,数字药盒和可摄入传感器.
性能差异很大:药物套 (灵敏度70-94%,特异性0-61%),数字药盒 (灵敏度25-99%,特异性69-100%),可摄入传感器 (灵敏度≥95%).
参与者选择是潜在偏见的最常见来源.

结论:

目前的证据表明,DAT在结核病药物剂量监测方面表现不佳且不一致.
存在显著的证据差距,特别是关于现实世界的程序设置.
未来的研究应该标准化绩效报告,并探索技术,设置和用户参与对DAT有效性的影响.

关键词:

全球健康全球健康公共卫生公共卫生系统性审查系统性审查结核病是一种疾病.

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