与疾病严重程度相关的SARS-CoV-2感染后的短期和长期中风风险:丹麦国家队列研究
Camilla Schade Skov1,2, Anton Pottegård3, Jacob Harbo Andersen3
1Department of Emergency Medicine, Odense University Hospital, Odense, Denmark camilla.schade.hansen@rsyd.dk.
BMJ open
|July 16, 2024
概括
在SARS-CoV-2 (导致COVID-19的病毒) 之后,中风的风险增加,特别是在住院患者中. 社区管理的病例没有显示长期中风风险增加.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 研究表明,住院患有SARS-CoV-2的患者中风的发病率很高.
- 在SARS-CoV-2感染后,疾病严重程度对中风风险的影响仍未得到充分研究.
研究的目的:
- 为了估计SARS-CoV-2检测阳性个体与检测阴性个体相比发生缺血性中风的风险.
- 在急性和感染后阶段根据疾病严重程度对中风风险进行分层.
主要方法:
- 一个全国性的丹麦基于登记册的队列研究.
- 包括2020年3月至2021年11月期间对所有丹麦成年人进行了SARS-CoV-2检测.
- 倾向性得分权重被用于控制混因素,计算分发危险比率 (SHR),将死亡作为竞争风险.
主要成果:
- 阳性SARS-CoV-2测试与与测试阴性个体相比,急性阶段的整体中风风险 (SHR 3.32) 显著增加.
- 在感染后的时期,急性感染期间住院的个人中风风险仍然很高 (SHR 1.85).
- 社区管理的SARS-CoV-2感染的个体没有增加长期中风风险 (SHR 1.01).
结论:
- SARS-CoV-2 感染与中风风险增加有关.
- 疾病的严重程度是影响感染后中风风险的关键因素.
- 轻度,社区管理的SARS-CoV-2感染似乎不会导致中风风险的长期增加.
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