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队列概况:瑞典肥胖和疾病发展研究 (ODDS),一个聚合的队列
Marisa da Silva1, Josef Fritz1,2, Innocent B Mboya1
1Department of Translational Medicine, Lund University, Malmö, Sweden.
BMJ open
|July 16, 2024
概括
瑞典肥胖和疾病发展研究 (ODDS) 追踪了超过420万个人的体重指数 (BMI) 和腰围 (WC). 这项大规模的研究将人体测量与疾病风险和死亡率联系起来,提供了强大的健康见解.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 临床研究 临床研究
背景情况:
- 瑞典肥胖和疾病发展研究 (ODDS) 是一项大规模的队列研究,旨在研究身体组成和健康结果之间的关系.
- 该研究利用瑞典国家登记册,旨在提供有关肥胖和疾病发展的可靠数据.
研究的目的:
- 建立一个全面的队列来研究体重指数 (BMI),腰围 (WC),以及它们与发病率和死亡率相关的变化.
- 分析人类测量对常见疾病和死亡原因风险的影响.
主要方法:
- 包括来自瑞典队列和国家登记册的420多万个人.
- 收集大量关于体重和腰围的数据,其中很大一部分是客观测量的评估.
- 在2019-2021年之前,使用国家登记册进行病率和死亡率的纵向随访.
主要成果:
- 该队列包括2,165,048名男性和2,130,811名女性,超过770万个体重评估和超过512,000个腰围评估.
- 随访时间的中位数超过了男性的31年和女性的19年,随访期间记录了大量的死亡.
- 对初步评估的分析显示,64-67%的个体体重正常,5%-10%的个体肥胖,性别之间的BMI中位数有所不同.
结论:
- 在ODDS研究的大型样本和延长后续期使得人类测量和健康风险的分析能够得到充分的分析.
- 预计将产生关于疾病风险,死亡率和特定亚组和较罕见疾病的结果的新发现.
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