在失脂症成年人中,随着时间的推移,在停止使用他类药物后,有机体血脂的血脂反应
Laura Alvarez-Jimenez1, Felix Morales-Palomo1, Alfonso Moreno-Cabañas2
1Exercise Physiology Lab at Toledo, University of Castilla-La Mancha, Spain.
概括
停用静止剂在4天内迅速增加LDL-c,总胆固醇和甘油三等血脂,表明没有持续的保护作用. 恢复他类药物有效地恢复脂质水平,显示出明显的生物反应.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 脱脂症患者经常停止使用他类药物治疗.
- 停止使用他类药物对动脉质风险的影响尚未完全理解.
- 停药后他类药物的潜在持续保护作用尚不清楚.
研究的目的:
- 调查他类药物的遗留效应是否会在停止服用后防止血液脂质立即增加.
- 为了确定在停止使用他类药物后异位性血脂特征变化的时间表.
主要方法:
- 在10名男性他类药物使用者中评估了禁食和食后异位动脉血脂样本.
- 在停止服用他类药物 (第0天) 之前,在停止服用他类药物后的4,7,15,30天以及在重新开始服用他类药物后的20天 (第50天) 进行了测量.
主要成果:
- 在停止使用他类药物后4天,血液LDL-c,总胆固醇 (CHOL) 和甘油三 (TG) 显著增加.
- 脂质增加在7-15天之间达到顶峰,显示出与基线相比的大幅度升高.
- 在脂质增加和他类药物的剂量或治疗时间之间没有发现相关性.
- 恢复他类药物治疗使脂质水平在20天内正常化.
结论:
- 该研究发现,没有证据表明他类药物对血脂的持续保护作用.
- 在停止使用他类药物仅4天后,异原性脂质水平迅速且显著上升.
- 重新开始使用他类药物证明了在恢复脂质样本到基线水平方面具有可重现的效果.
相关概念视频
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
621
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
621
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
152
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
152
01:14Time Course of Drug Effect
2.0K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.0K
01:38Inflammation
53.3K
Overview
53.3K
01:18Lipids: Dietary Sources and Requirements
718
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
718
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
54
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
54