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预先认知和第一季度对农药的暴露以及与死产的关联

Melissa A Furlong¹, Kimberly C Paul², Kimberly L Parra³

¹Department of Community, Environment, and Policy, Environmental Health Sciences, University of Arizona, Tucson, Arizona, United States.

American journal of epidemiology

|July 16, 2024

概括

在怀孕前和怀孕初期接触农药与死产有关. 特定的化学物质,如有机酸盐和甲酸盐,显示风险增加,突出显示孕妇对环境健康的关注.

科学领域:

环境流行病学环境流行病学
生殖健康生殖健康
毒理学毒理学毒理学

背景情况:

农药暴露是导致妊娠不良后果的潜在危险因素.
关于产前接触农药和死产的研究有限.
了解这些关联对于公共卫生干预至关重要.

研究的目的:

调查在怀孕前的窗口和怀孕的第一个三个月期间与死产产生的农药暴露之间的联系.
确定与死产风险增加相关的特定农药.
为了利用与农药使用和出生记录相关的大量数据集.

主要方法:

将亚利桑那州的农药使用记录 (2006-2020年) 与出生证明联系起来.
估计生活在500米以内农药应用和死产之间的关联.
分析了使用二进制和连续测量的甲酸盐,有机酸盐 (OP) 和碳酸盐暴露量.
采用负对照暴露框架与日志双项回归.

主要成果:

孕前暴露于某些农药,包括OP类,齐夫卢,泽塔-赛珀美,马拉,卡巴里尔和普罗帕莫碳水化合物,与死产有关.
第一个三个月内暴露于芬甲,甲,OP作为一种类型,酸盐和甲酸盐化物也与死产有关.
当使用连续测量农药应用 (日志磅,日志英) 时,关联仍然是一致的.

结论:

在怀孕前期和怀孕第一季度暴露于农药可能与死产风险增加有关.
特定的农药需要进一步调查,因为它们是死产的潜在环境风险因素.
这些发现强调了在生殖健康研究和政策中考虑环境暴露的重要性.

关键词:

碳酸盐农药的使用情况环境暴露环境暴露胎儿死亡胎儿死亡流产流产流产流产有机酸盐杀虫剂有机酸盐农药杀虫剂杀虫剂杀虫剂类杀虫剂类杀虫剂一个死产的死亡.

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