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Updated: Jun 21, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

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RNF213促进Treg细胞分化,通过促进K63结合的无化和FOXO1的核转位来促进Treg细胞分化

Xiaofan Yang1, Xiaotong Zhu2, Junli Sheng1

  • 1The Second Affiliated Hospital, The Second School of Clinical Medicine, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, China.

Nature communications
|July 16, 2024
PubMed
概括

环指蛋白213 (RNF213) 促进调节性T (Treg) 细胞分化,并减少自身免疫性疾病. 这种蛋白质对于IFN-β在多发性硬化症 (MS) 的治疗作用至关重要.

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