在成年人中,维生素B1摄入量和高尿路血症之间的关联
Yi-Ming Li1,2, Xiao-Hu Xu1,2, Xiao-Fan Xu1,2
1College of Clinical Medicine, Jining Medical University, Jining, Shandong Province, China.
Scientific reports
|July 16, 2024
概括
饮食维生素B1摄入量显示,在成年男性中,对高尿血 (HU) 有保护性关联. 更高的摄入量与男性患HU风险降低相关,但女性并非如此.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 超尿血 (HU) 是一种与各种健康问题相关的疾病.
- 饮食因素,包括维生素B1 (胺),可能会影响HU风险.
- 关于食维生素B1和HU之间的特定关联,研究有限.
研究的目的:
- 调查饮食维生素B1摄入量与美国成年人中高尿素血的患病率之间的关系.
- 要分别对男性和女性分析这种关联.
- 探索潜在的剂量反应关系和与血清尿酸水平的关联.
主要方法:
- 这是一项采用5750名美国成年人的数据进行的横截面研究 (国家健康和营养检查调查,2017-2020年).
- 通过24小时召回评估的食维生素B1摄入量.
- 使用多变量逻辑回归和受限立方线 (RCS) 分析来确定关联和趋势.
主要成果:
- 在研究人群中,高尿路血的患病率为18.90%.
- 在男性中,更高的维生素B1摄入量五分之一与显著降低的高尿路血症风险相关 (P-趋势=0.028).
- 没有发现维生素B1摄入量与女性高尿路血症风险之间有显著的关联 (P-趋势=0.876).
- 在男性中,维生素B1摄入量和血清尿酸水平之间观察到负相关性.
结论:
- 饮食维生素B1摄入量与成年男性的高尿路血症风险有负面关联.
- 这些发现表明,胺在预防男性高尿血症方面具有潜在的保护作用.
- 需要进一步的研究来证实这些发现,并探索女性的机制.
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