里法布丁装载的可吸入β-葡萄糖微粒为肺结核的药物输送系统
Firoz Ahmad1,2, Shad Ahmad3, Tarun Kumar Upadhyay4
1IIRC-3 Immunobiochemistry Lab, Department of Biosciences, Integral University, Lucknow, UP, 226026, India.
Scientific reports
|July 16, 2024
概括
由酵母衍生的β-葡萄糖制成的新的可吸入微粒有效地提供抗肺结核药物. 这些β-葡萄糖微粒在治疗肺结核方面表现有前途,毒性降低,生物可用性提高.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 制药科学 制药科学
背景情况:
- 结核病 (TB) 治疗面临着传统药物输送途径的挑战.
- 吸入式微粒系统为结核病治疗提供了增强的肺沉积和改善药物的生物可用性.
- 酵母衍生的β-葡萄糖是一种生物相容的聚合物,被用作生物分子的载体,作为巨细胞吸收的PAMP.
研究的目的:
- 开发和描述可吸入的β-葡萄糖微粒,用于针对性地输送抗结核病药物.
- 评估开发系统的药物加载效率,颗粒特性和生物相容性.
- 评估β-葡萄糖微粒作为肺结核的宿主导药物输送系统的潜力.
主要方法:
- 用l-leucine作为辅助剂制备了β-葡萄糖微粒.
- 使用HPLC确定药物加载效率.
- 分析了粒子大小,形态学,组成,空气动力学特性 (MMAD,GSD),热稳定性 (DSC) 和巨细胞的体外/体外细胞分解.
主要成果:
- 该研究在β-葡萄糖微粒中实现了70%的Rifabutin加载效率.
- 粒子具有最佳尺寸 (2-4微米),球形和可吸入的空气动力学特性 (MMAD,GSD).
- 微粒的毒性高达80μg/ml,并且在体外和体内容易被巨细胞化.
结论:
- 可吸入的β-葡萄糖微粒代表了肺结核的有前途的药物输送系统.
- 开发的系统提供了高效的药物加载,有针对性的肺部输送,以及巨细胞增强的细胞吸收.
- 这项研究为设计使用基于β-葡萄糖的纳米颗粒的针对结核病的先进宿主导治疗提供了基础.
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