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Updated: Jun 21, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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染色体重塑剂作为治疗点

Hayden A Malone1,2, Charles W M Roberts3

  • 1Division of Molecular Oncology, Department of Oncology, and Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature reviews. Drug discovery
|July 16, 2024
PubMed
概括

在SWI/SNF (Switch/Sucrose Non-Fermentable) 染色体重塑剂中的突变在癌症和发育障碍中很常见. 针对这些复杂物及其合成致命伙伴提供了有希望的治疗策略.

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