血小板丰富的血注射声在良性声乐病理中的声
Georgia Mackay1, Jacqui Allen2
1Department of Surgery, University of Auckland, Private Bag 91019, Grafton Auckland, New Zealand.
概括
发声中注射富血小板血 (PRP) 是安全的和可行的治疗失声症. 这种治疗提供了显著的音声效益,并减少了在患有良性声障碍的患者的声乐努力.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 再生医学是一种再生医学.
- 声音科学 声音科学
背景情况:
- 由声病理引起的失声症,如痕,缩,或炎症,其治疗选择有限.
- 富血小板血 (PRP) 具有抗炎和再生性质,使其成为潜在的治疗剂.
- PRP为其他组织工程疗法提供了替代方案,可能避免相关风险.
研究的目的:
- 评估PRP的可行性,音声效应,患者满意度和声 (VF) 注射的耐久性.
- 评估PRP作为治疗由良性声障碍引起的失声症.
主要方法:
- 一项前性队列研究 (III级) 包括因VF痕,缩,或炎症病变而导致的听力障碍患者.
- 患者在办公室内接受双边PRP注射到声中.
- 结果在1周,1,3个月和6个月后使用GRBAS尺度,最大发音时间 (MPT),声疲劳指数 (VFI),语音障碍指数 (VHI-10) 和强光镜进行评估.
主要成果:
- 75名PRP注射给了48名患者,没有任何不良反应.
- 从基线 (21.73) 到6个月 (15.62,p < 0.001) 的VHI-10得分显著改善.
- 二次结果 (VFI,MPT,GRBAS) 也显示出显著的改善,72.3%的人报告改善 (利克尔特尺度),95.7%的人会考虑未来的PRP注射.
结论:
- 在办公室内为声注射PRP是可行的,并且在治疗良性VF疾病时是安全的.
- PRP注射可以带来显著的音声效益和减少声乐努力.
- 一次PRP注射可能足以在某些患者中提供持续改善.
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