在歌鸟中,IGF-1会诱导特定性别的氧化损伤和死亡
Ádám Z Lendvai1, Zsófia Tóth2,3,4, Katharina Mahr5
1Department of Evolutionary Zoology and Human Biology, University of Debrecen, Debrecen, Hungary. az.lendvai@gmail.com.
Oecologia
|July 16, 2024
概括
胰岛素样生长因子1 (IGF-1) 的升高增加了雄性歌鸟的氧化应激,但不是雌性. 在男性中,氧化平衡的快速恢复与更好的生存率相关,这表明对IGF-1的性别特异性反应.
科学领域:
- 内分泌学 在内分泌学.
- 生态生态学 生态生态学
- 老年学是一门学科.
背景情况:
- 胰岛素类生长因子1 (IGF-1) 影响衰老和死亡率,高水平与氧化应激有关.
- 之前对IGF-1和氧化应激效应的研究仅限于实验室动物.
- 了解野生种群的寿命决定因素对于保护和生态研究至关重要.
研究的目的:
- 为了研究高水平IGF-1对野生鸟类氧化应激的影响.
- 为了确定IGF-1诱导的氧化应激是否在自由生活的动物中因性别而异.
- 探索IGF-1,氧化应激和野生脊椎动物的生存之间的关系.
主要方法:
- 使用被囚禁的胡须 (歌鸟) 进行受控实验.
- 慢释放IGF-1微球的皮下注射,以提高激素水平.
- 测量氧化损伤 (血麦隆迪甲基) 和评估生存率.
主要成果:
- 在IGF-1治疗后,男性的脂质氧化损伤显著增加,在四天内消失.
- 在接受IGF-1治疗后,女性的氧化损伤没有显著变化.
- 较高的初始IGF-1和较低的治疗后氧化损伤与男性的生存率提高有关.
结论:
- 雄性歌鸟似乎比雌性更容易受到IGF-1诱导的氧化应激.
- 快速恢复氧化平衡的能力可能是男性生存的关键因素.
- IGF-1水平的自然变化可能代表增长,衰老和健康之间的最佳平衡.
更多相关视频
11:49A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates
Published on: August 21, 2018
6.6K
09:20Visualizing the Effects of Oxidative Damage on Drosophila Egg Chambers using Live Imaging
Published on: April 10, 2021
3.7K
相关概念视频
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
The Ratio of X Chromosome to Autosomes
8.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.5K
Lethal Alleles
15.4K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.4K
Dosage Compensation
6.1K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
6.1K
Mate Choice
8.0K
Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
8.0K
