基于全基因组重新测序的内蒙古克什米尔山羊 (埃兰山亚型) 的遗传多样性分析
Ruijun Wang1, Xinle Wang1, Yunpeng Qi1
1College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
BMC genomics
|July 16, 2024
概括
内蒙古克什米尔山羊 (IMCGs) 显示中等的遗传多样性和低亲属关系,表明有效的保护. 然而,需要继续努力,以防止血系损失,并保护宝贵的生殖质资源.
科学领域:
- 动物基因组学 动物基因组学
- 保护遗传学 保护遗传学
- 畜牧养殖 畜牧养殖 畜牧养殖
背景情况:
- 内蒙古克什米尔山羊 (IMCGs) 是一种有价值的中国本土品种,以优越的克什米尔品质而闻名.
- IMCGs的遗传资源受到与世界性的品种和不充分的保护系统交叉繁殖的威胁.
研究的目的:
- 评估IMCGs的保护有效性.
- 保护和利用IMCGs的纯种子生殖质资源.
- 分析IMCG群体内的遗传多样性,亲属关系,家庭结构和近亲繁殖.
主要方法:
- 分析了225个随机选择的IMCG的重新测序数据.
- 在34,248,064个SNP地点进行了质量控制,选择了12,700,178个高质量的SNP.
- 分析使用了Plink,GCTA和R软件来评估遗传参数,包括异卵性,亲属关系和同卵性 (ROH) 的运行.
主要成果:
- 观察到中等的遗传多样性,平均MAF (0.253),PIC (0.284) 和SHI (0.530).
- 平均观察到的异构性 (Ho) 是0.355,预期的异构性 (He) 是0.351.
- 检测到低亲属关系和近亲繁殖 (ROH的平均近亲繁殖系数:0.026),在23只公羊中确定了10个家庭.
结论:
- IMCGs表现出适度的多态性和低亲属性,这表明有效的保护策略已经到位.
- 在保存的种群中发现了低水平的内生繁殖.
- 防止血系损失对于长期维持IMCG生殖质资源至关重要.
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