适度更高的时间范围门可以改善COVID-19复杂的2型糖尿病患者的预后
Riping Cong1, Jianbo Zhang1,2, Lujia Xu1
1Department of General Practice, Qilu Hospital of Shandong University, Jinan, Shandong, China.
80-190毫克/分升的时间范围 (TIR) 门预测了COVID-19患者的结果 2型糖尿病 (T2D). 更高的TIR,特别是超过54.73%,与这些患者的不良结果减少有关.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 流行后的COVID-19急剧增加使得2型糖尿病 (T2D) 患者的管理复杂化.
- 标准时间范围 (TIR) 血糖监测目标可能难以实现.
- 需要一个临床实用的TIR值来评估COVID-19的T2D患者的预后.
研究的目的:
- 为了研究一个更临床实用的TIR门,COVID-19患者的T2D.
- 检查该TIR值与患者预后之间的关联.
- 为了在这个群体中建立一个适当的TIR参考范围.
主要方法:
- 评估了63名COVID-19的T2D患者.
- 根据复合终点将患者分为有利和不利的结果组.
- 使用连续血糖监测计算的TIR,时间下方范围 (TBR) 和时间上方范围 (TAR).
- 使用后勤回归和统计分析来将葡萄糖变化与预后相关联.
主要成果:
- 80-190 mg/dL的TIR值与有利的结果显著相关.
- 每增加1%的TIR与3.70%的不良结果风险降低相关.
- 最佳的TIR门 (尤登指数) 是54.73% (灵敏度为58.30%,特异性为77.80%).
- 在200-230 mg/dL之间的时间超出范围 (TAR) 显著增加了不良结果的可能性.
结论:
- 80-190 mg/dL的TIR值证明了T2D患者COVID-19预后的高预测价值.
- >54.73%的TIR与不良结果风险降低有关.
- 研究结果为改善这一患者群体的治疗结果提供了关键的见解.
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