传染病儿童死亡率的预测生物标志物:全国范围的数据分析
Shinya Miura1,2, Tomohiro Katsuta1, Yukitsugu Nakamura1
1Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.
Frontiers in pediatrics
|July 17, 2024
概括
常见的感染生物标志物,如C反应蛋白和白细胞计数,对于预测儿童死亡率是不可靠的. 对于儿科传染病的更有效的生物标志物包括pH值,前列血时间-国际规范化比率,和prokalcitonin.
科学领域:
- 儿童传染病 儿童传染病
- 临床生物标志物 临床生物标志物
- 关键护理医学 关键护理医学
背景情况:
- 生物标志物对于识别感染高风险儿童至关重要.
- 很少有研究评估了生物标志物对儿科传染病死亡率的预测价值.
研究的目的:
- 评估各种生物标志物对被诊断患有传染病的儿童死亡率的预测能力.
主要方法:
- 分析了来自日本200多家急症医院的住院患者数据库 (2012-2021年).
- 包括接受血培养并接受抗菌药物治疗的儿童.
- 使用接收器运行特征曲线 (AUC) 下的面积来评估生物标志物的区分能力.
主要成果:
- 在11365名疑似感染的儿童中,有100名 (0.9%) 死亡.
- C-反应蛋白 (AUC:0.44) 和白细胞计数 (AUC:0.45) 的预测能力有限.
- pH (AUC:0.77),前列血时间-国际规范化比率 (AUC:0.77),和公素 (AUC:0.76) 显示出对死亡率有很强的区分能力.
结论:
- "C反应蛋白"和白细胞计数可能不是预测儿科感染死亡率的可靠指标.
- pH值,前列血时间-国际规范化比率,以及公素作为预测生物标志物显示出有前途.
- 进一步的研究是有必要的,以探索这些有前途的生物标志物在儿科传染病死亡率预测.
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