评估神经刺激的触发延迟和同步在不同的通风模式
Ishmael Bentley1, Frank T Jocewicz1, Bruce D Johnson2
1Stimdia Medical Inc., Mendota Heights, MN, United States.
Frontiers in physiology
|July 17, 2024
概括
一种新型的神经刺激装置在吸入时准确地传递电刺激,以防止隔膜缩. 这种设备在模拟的机械通风场景中没有加剧呼吸不一致.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 机械通风可能会导致隔膜缩,原因是呼吸需求-通风器支不匹配.
- 正在探索神经刺激,以防止机械通风患者的隔膜缩.
研究的目的:
- 评估一种新型的神经刺激装置,以评估其能够提供准确的灵感刺激的能力.
- 评估设备是否会在机械通风过程中加剧呼吸不一致.
主要方法:
- 使用了一台电机模拟模型,配备呼吸模拟器和机械呼吸机.
- 测量了设备的刺激时间和触发比 (1:1和1:4).
- 与该设备一起测试了各种模拟的不一致场景.
主要成果:
- 该设备在预期时间提供刺激时实现了高精度 (99.79%为1:1,99.72%为1:4).
- 平均吸入滞后时间为36.10 ± 10.50毫秒;平均呼出滞后时间为16.61 ± 3.61毫秒.
- 该设备没有加剧模拟的呼吸不一致性,包括错误触发和时间失调.
结论:
- 这种新型神经刺激装置按预期运行,提供精确的电刺激疗法.
- 该设备与机械通风一起使用是安全的,因为它不会恶化呼吸不一致.
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