通过抗血管内皮生长因子对两例视网膜动脉宏动脉瘤的管理
1Department of Ophthalmology, Yonezawa City Hospital, Yonezawa, Japan.
Case reports in ophthalmology
|July 17, 2024
概括
抗血管内皮生长因子 (VEGF) 注射有效治疗与年龄相关的黄斑变性和带有视网膜动脉宏动脉瘤 (RAM) 的糖尿病黄斑胀. 这两种情况都得到解决,RAM消失,治疗后视力敏性得到改善.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 与年龄相关的黄斑变性 (AMD) 和糖尿病黄斑 (DME) 是导致视力丧失的主要原因.
- 视网膜动脉宏动脉瘤 (RAM) 是一种血管异常,可以发生在这些条件下.
- 目前对RAM的治疗方法有限,其与AMD或DME结合的治疗需要进一步调查.
研究的目的:
- 评估抗血管内皮生长因子 (VEGF) 静脉内注射在患有AMD或DME和并发性RAM的患者中的疗效.
- 评估抗VEGF治疗对黄斑胀/出血,RAM分辨率和视力敏度的影响.
主要方法:
- 介绍了两个病例:一个是AMD,一个是DME,两者同时存在RAM.
- 患者接受了多次抗VEGF药物 (贝瓦齐祖马布或拉尼比祖马布) 的静脉内注射.
- 用于诊断和监测的 Fundus fluorescein血管学 (FA) 和光学连贯性断层扫描 (OCT).
主要成果:
- 在这两种情况下,抗VEGF注射导致斑点或出血的解决.
- 视网膜动脉大动脉瘤 (RAM) 在治疗后在两位患者中均消失.
- 在抗VEGF治疗后,这两名患者的视力明显改善.
结论:
- 腹腔内抗VEGF注射似乎是AMD或DME复杂的RAM患者的有效治疗方法.
- 尽管不是标准的适应症,但积极的结果表明,在扩大抗VEGF治疗用于RAM的使用方面,它可能发挥作用.
- 需要进一步的研究来证实这些发现,并探索使用抗VEGF治疗来解决RAM背后的机制.
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