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Updated: Jun 21, 2025

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识别破坏WDR5-MYC蛋白质与蛋白质相互作用的5-thiocyanatothiazol-2-amines

Haiyang Wang1, Yihui Zhou1,2, Li Lu1

  • 1Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

ACS medicinal chemistry letters
|July 17, 2024
PubMed
概括

研究人员发现了新的5-thiocyanatothiazol-2-amine化合物,这些化合物破坏了WDR5-MYC相互作用,这是MYC驱动癌症的关键目标. 这些化合物表现出强大的抑制活性和细胞疗效,提供了一种新的治疗策略.

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