由于从反动物获得的原蛋白和来自骨的等酸,造成的BSE风险
EFSA journal. European Food Safety Authority
|July 17, 2024
概括
牛形脑病变 (BSE) 从动物制造的凝和原中传播的风险非常低,牛或小反动物中没有新病例的概率为99%-100%.
科学领域:
- 兽医流行病学 兽医流行病学
- 食品安全科学 食品安全科学
- 风险评估建模风险评估建模
背景情况:
- 来自绵羊,山羊或牛骨的凝和原是常见的食品和料成分.
- 人们担心这些产品可能会传播牛形脑病变 (BSE).
- 欧洲法规规范这些材料的生产,以减轻风险.
研究的目的:
- 量化估计从反动物骨头中获得的等和原蛋白引起的BSE感染风险.
- 评估通过口服接触这些产品在牛和小反动物中产生新的BSE病例的可能性.
- 确定和讨论人类和动物的潜在暴露途径.
主要方法:
- 开发了一种定量风险评估模型,以估计凝批次中的BSE传染性 (CoID50).
- 模拟的场景使用反动物的骨头,考虑到高传染性组织.
- 综合流行病学数据,物种屏障效应和剂量反应关系.
主要成果:
- 在牛或小反动物中通过口服接触等拉丁/原蛋白产生新的BSE病例的概率估计为99%-100% (几乎可以肯定的).
- 该模型考虑了高传染性组织可能仍然附着在骨头上的场景.
- 虽然确定了人类暴露途径,但由于未定量的传播障碍,定量风险评估是有限的.
结论:
- 根据现行法规生产的等和原蛋白在反动物种群中对BSE传播的风险是可以忽略不计的.
- 对人类来说,物种障碍很大,这表明与反动物相比,风险明显较低.
- 当前的知识,流行病学数据和行业实践支持这些产品在BSE传播方面的安全性.
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