患者的炎症和代谢状态突然发作的神经神经感官听力损失
Jônatas Bussador do Amaral1, Kelly Abdo Peron1, Tracy Lima Tavares Soeiro1
1ENT Research Lab, Department of Otorhinolaryngology-Head and Neck Surgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Frontiers in neurology
|July 17, 2024
概括
突然感觉神经听力损失 (SSNHL) 患者表现出炎症标记物的变化. 瘤亡因子-α (TNF-α) 水平与听力恢复相关,这表明它有可能成为SSNHL患者的预后因素.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 代谢医学是一种代谢医学.
背景情况:
- 突然感觉神经听力损失 (SSNHL) 是一种具有多因素原因的耳部紧急情况.
- 病理生理学可能涉及耳微环境或神经系统的变化,影响听力恢复.
- 识别SSNHL的系统预后因素对于及时干预至关重要.
研究的目的:
- 评估SSNHL患者的代谢和炎症变化.
- 为了确定与听力恢复相关的系统参数.
- 探索SSNHL中的特定细胞因子和代谢标记物的预后价值.
主要方法:
- 30名SSNHL患者被监测了4个月.
- 周围血液样本是在7日,30日和120日收集的.
- 量化的血清细胞因子 (IFN-γ,TNF-α等等) ),代谢概况和听力测试.
主要成果:
- 在大多数血清学参数中没有观察到显著变化.
- 干扰素- (IFN-γ) 水平在第7天和第30天之间下降了36.3%.
- 瘤亡因子-α (TNF-α) 和阿迪波内克丁水平随着时间的推移显著下降,与听力恢复相关.
结论:
- 在SSNHL的急性阶段,血清细胞因子水平波动.
- TNF-α水平与听力恢复有显著的相关性.
- IFN-γ,TNF-α和阿迪波内克丁可以作为SSNHL临床改善的潜在生物标志物.
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