慢性牙周炎和肺癌风险:全国范围的队列研究
Bo-Guen Kim1, Hyun Lee1, Sun-Kyung Lee1,2
1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Frontiers in oncology
|July 17, 2024
概括
慢性牙周炎 (CP) 显著增加了肺癌的风险. 这种风险在严重的CP病例,女性,从不吸烟者和肥胖个体中更高,这突显了口腔健康和肺部健康之间的关键联系.
科学领域:
- 口腔健康和瘤学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 慢性牙周炎 (CP) 与肺癌风险之间的关系需要进一步研究.
- 以前的研究还没有完全阐明牙周病对肺癌发病率的长期影响.
研究的目的:
- 调查慢性牙周炎与患肺癌的风险之间的关联.
- 通过大规模的全国数据集提供强有力的证据.
主要方法:
- 一项全国性的队列研究,利用韩国国家医疗保险服务国家样本队列的数据.
- 从2005年到2019年,包括72,658名被诊断患有CP的个人 (CP队列) 和72,658名没有CP的匹配对照 (非CP队列).
主要成果:
- 患有CP的个体表现出发生性肺癌的风险明显更高 (aHR = 2.27).
- 与对照组相比,轻度 (2.45倍) 和中度至重度 (2.10倍) 的肺癌风险在轻度 (2.45倍) 和中度至重度 (2.10倍) 的肺癌组都增加.
- 肺癌风险增加特别在40-59岁的年龄组,女性和患有CP的从未吸烟者中被注意到.
结论:
- 慢性牙周炎是发生肺癌的重要危险因素.
- 风险随着CP的严重程度的增加而增加,尤其影响女性,从未吸烟者和肥胖者.
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