在月经周期和更年期期间,呼出的二氧化碳的变化
Tomer Cramer1, Shlomo Yeshurun1, Merav Mor1
1Metaflow Ltd., Tel-Aviv, Israel.
Digital biomarkers
|July 17, 2024
概括
呼出的二氧化碳 (CO2) 水平在月经周期期间表现出周期性模式,受到激素的影响. 接受荷尔蒙替代疗法的更年期妇女与不接受荷尔蒙替代疗法的妇女相比,二氧化碳含量不同.
科学领域:
- 代谢生理学 代谢生理学
- 妇女健康 妇女健康
- 内分泌学 在内分泌学.
背景情况:
- 月经周期 (MC) 涉及影响女性新陈代谢和生理学的荷尔蒙波动.
- 呼出的二氧化碳 (CO2) 是代谢燃料利用的标志物.
- 了解MC和绝经期间的代谢变化对于妇女健康和生育管理至关重要.
研究的目的:
- 通过使用Lumen设备测量出的呼气CO2模式来调查整个月经周期的代谢变化.
- 为了探索更年期妇女的二氧化碳水平的差异,有和没有激素替代疗法 (HRT).
主要方法:
- 一项回顾性队列研究分析了来自3,981名Lumen用户的呼出CO2数据.
- 参与者包括患有湿疹的女性和经期更年期的女性,有或没有HRT.
- 线性混合模型被用来评估跨MC阶段和更年期组之间的CO2变化.
主要成果:
- 湿疹女性表现出周期性CO2模式,在月经,雌激素和排卵阶段的水平升高.
- 在排卵后和月经前阶段,二氧化碳水平下降,尽管周期长度有所不同,但仍有一致的模式.
- 没有HRT的更年期妇女的二氧化碳水平与HRT的妇女相比显著不同,她们的二氧化碳水平较低.
结论:
- 显著的二氧化碳模式与月经周期相对应,表明荷尔蒙对新陈代谢的影响.
- 更年期妇女的二氧化碳配置因HRT的存在或不存在而改变.
- 呼出CO2监测可以作为跟踪MC和理解更年期代谢变化的工具.
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