阿片类药物使用障碍和作为管理辅助的作用 (OUDARYAM):随机对照试验的研究协议
Hemant Bhargav1, Bharath Holla1, Jayant Mahadevan2
1Department of Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, 560029, India.
Wellcome open research
|July 17, 2024
概括
这项研究调查了的研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 补充医学是一种补充医学.
背景情况:
- 阿片类药物使用障碍 (OUD) 提出了重大的临床挑战.
- 对OUD的标准治疗通常需要辅助疗法来改善结果.
- 人们越来越认识到对治疗成和相关症状的潜在好处.
研究的目的:
- 为了评估六个月干预作为标准OUD治疗的辅助措施的有效性.
- 探索在OUD中的作用背后的神经生物学和心理机制.
- 评估对临床结果的影响,如禁欲,疼痛和渴望.
主要方法:
- 一个单盲,随机对照试验,涉及印度164名OUD患者.
- 干预组接受标准治疗加上24周的计划 (面对面和远程).
- 对照组仅接受标准治疗;在基线,2,12和24周的评估.
主要成果:
- 主要结局包括临床测量 (禁欲,疼痛,渴望) 和神经成像数据 (奖励电路激活,功能连接).
- 二次结果包括压力,焦虑,睡眠,认知和生理标志物.
- 机理学研究包括fMRI,β-endorphin水平,以及GABA的MRS.
结论:
- 这项研究将提供关于在OUD治疗中的有效性和机制的见解.
- 这些发现可能支持将纳入OUD综合护理中.
- 结果将通过出版物,会议和社交媒体传播.
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