血液炎症指标与乳头甲状腺癌的预后之间的关联:叙述性综述
Yuan Cai1,2, Lingqian Zhao3, Yu Zhang2
1Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Gland surgery
|July 17, 2024
概括
手术前的炎症标志物,如淋巴细胞与单细胞的比率 (LMR) 和中性粒细胞与淋巴细胞的比率 (NLR),可以表明乳头甲状腺癌 (PTC) 的预后. 低的LMR和高的NLR/血小板-淋巴细胞比率 (PLR) 与PTC患者的较差结果有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 乳头甲状腺癌 (PTC) 是最常见的甲状腺癌,通常是惰的,但有时是攻击性的.
- 血液中的手术前炎症指数 (LMR,NLR,SII) 被作为甲状腺癌的非特异性标志物进行了探索.
- 了解炎症标志物在PTC预后中的作用对于患者管理至关重要.
研究的目的:
- 审查手术前炎症因素和PTC患者的结果之间的关联.
- 为了确定预测乳头甲状腺癌的预后的血液指标.
- 综合当前关于炎症标志物和PTC患者结局的证据.
主要方法:
- 2014年1月至2023年12月出版的英语文章的叙事评论.
- 在PubMed和Web of Science数据库中进行的搜索.
- 包括检查血液指标和PTC预后的研究 (TNM分期,生存,复发,转移).
主要成果:
- 低的淋巴细胞与单细胞比率 (LMR) 通常与不良的PTC预后相关.
- 高的中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 经常与不良结果有关.
- 单个细胞计数的预后价值仍然不清楚.
结论:
- 最少侵入性的血液指标为精确的PTC预后管理提供了潜力.
- 关于这些标记物的发现往往是相互矛盾的,需要验证.
- 需要包括年龄等因素在内的前性多中心研究来确认预后价值.
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