在严重的渐进性多发性硬化症的认知功能
Dejan Jakimovski1, Robert Zivadinov1,2, Zachary Weinstock1
1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.
Brain communications
|July 17, 2024
概括
在严重的渐进性多发性硬化症 (MS) 中,认知障碍很普遍. 专门设计的听力测试显示,对MS患者的认知处理速度进行评估是有前途的,与大脑体积减少有关.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 神经免疫学 神经免疫学
背景情况:
- 认知障碍显著影响多发性硬化症 (MS) 患者的生活质量.
- 由于测试挑战,严重进展性多发性硬化症患者的认知功能尚未得到充分研究.
- 对于患有严重多发性硬化症的人来说,传统的神经心理测试很难.
研究的目的:
- 描述严重进展性多发性硬化症患者的认知表现.
- 为了比较严重多发性硬化症患者的认知功能与不太残疾的多发性硬化症患者.
- 探索认知表现与MSM结果之间的关系.
主要方法:
- 利用处理速度的听觉测试 (ATPS) 来进行非运动认知评估.
- 管理了多发性硬化症简要国际认知评估 (BICAMS) 电池.
- 在匹配的多发性硬化队伍中,分析了病变和体积大脑测量的MRI.
主要成果:
- 严重的MS患者在所有认知领域表现明显差.
- 认知处理速度,学习,记忆和语言受到影响最大.
- 处理速度的听力测试显示,在严重的MS中,完成率高于符号数字模式测试.
结论:
- 听觉,非运动认知测试为严重进展性MS提供了敏感的选.
- 严重多发性硬化症的认知缺陷与身体残疾相关.
- 减少的乳头和皮质灰质体积与MS的认知障碍有关.
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