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基于生物标志物的淋巴细胞过率的评估 估计在淋巴细胞疾病中的方程
Antara Mondal1,2, Christina Kobe3, Laura H Mariani3
1Division of Biostatistics, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
Glomerular diseases
|July 17, 2024
概括
使用cystatin-C估计膜过率 (GFR) 对成年人来说可靠,但对儿童来说不那么可靠. 随着GFR的增加,患有淋巴细胞疾病的儿科患者需要更频繁的囊素-C测量.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物 生物标志物
- 儿科脏病学 儿科脏病学
背景情况:
- 淋巴膜过率 (GFR) 的估计通常依赖于血清肌素和/或囊素-C生物标志物.
- 这些生物标志物的比较影响GFR估计在球细胞疾病患者仍然不清楚.
- 治愈淋巴结核瘤 (CureGN) 队列为这项调查提供了有价值的数据集.
研究的目的:
- 为了比较使用血清肌素和囊素-C的GFR估计方程,在患有淋巴细胞疾病的儿童和成年人中.
- 评估CureGN队列中不同GFR估计方程之间的一致性.
- 确定与GFR估计差异相关的因素.
主要方法:
- 同一天匹配的血清肌素和囊素-C测量被用于估计GFR.
- 使用类内相关系数来评估"25岁以下" (U25) 和CKD-Epi方程之间的一致性.
- 多变量线性混合效应模型确定了影响eGFR差异的因素.
主要成果:
- 在25岁以下的参与者中,在U25方程之间观察到适度一致 (0.731).
- 在18岁及以上的参与者中,在CKD-Epi方程中发现了优异的一致性 (0.891-0.978).
- 年龄较小和eGFR值较高与GFR估计方程之间的差异较大有关.
结论:
- CKD-Epi方程对成年人来说显示出很好的一致性,支持继续单独使用血清肌氨酸来估计GFR.
- 与U25方程的适度一致性突出显示,需要在儿童和年轻人中更频繁地对囊C进行监测,特别是随着EGFR的增加.
- 这些发现对优化GFR评估在不同年龄组的淋巴细胞疾病有影响.
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