在老年急性髓性白血病中转化生长因子-β1和血管内皮生长因子水平和与预后的相关性
Wan Li1, Sheng-Yu Ma1, Hui-Ying Zhao2
1Department of Hematology, Suzhou Hospital of Anhui Medical University, Suzhou 234000, Anhui Province, China.
World journal of clinical cases
|July 17, 2024
概括
较低的血管内皮生长因子 (VEGF) 和更高的转化生长因子-β1 (TGFβ1) 水平与急性髓性白血病 (AML) 患者的更好的结果相关. 这些生物标志物有助于个性化AML治疗策略.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 急性髓性白血病 (AML) 的特征是未成熟的造血细胞积累,导致造血功能受损.
- 目前的AML治疗和预后对许多患者来说仍然不令人满意.
研究的目的:
- 研究血管内皮生长因子 (VEGF) 和转化生长因子-β1 (TGFβ1) 表达在患有AML的老年人中的预后意义.
- 探索VEGF和TGFβ1水平与患者的结果之间的相关性.
主要方法:
- 对80名AML患者和56名健康对照者的回顾性分析.
- 在骨髓单核细胞中使用逆转录聚合酶链反应量化VEGF和TGFβ1mRNA表达.
- 卡普兰-梅尔生存分析和考克斯比例危险建模来评估预后因素.
主要成果:
- 与非响应者相比,在完全响应者中观察到较低的VEGF和较高的TGFβ1表达.
- VEGF和TGFβ1水平与白细胞,血小板,血红蛋白和不成熟细胞计数有显著的相关性.
- 高TGFβ1和低VEGF表达与改善的整体存活率 (OS) 和无病存活率 (DFS) 相关.
- VEGF,TGFβ1和血小板/白细胞计数被确定为OS和DFS的独立预后因素.
结论:
- 减少VEGF和增加TGFβ1表达是AML预后的有价值指标.
- 这些发现支持基于生物标志物表达的AML患者临床治疗策略的个性化.
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