针对复发或耐火的威尔姆斯瘤的含贝瓦西祖马布的治疗
Sarah Al-Jilaihawi1, Filippo Spreafico2, Annelies Mavinkurve-Groothuis3
1Department of Paediatric Oncology, Bristol Royal Hospital for Children, Bristol, UK.
Expert review of anticancer therapy
|July 17, 2024
概括
贝瓦西祖马布在与其他药物结合时,在治疗复发性或耐火性威尔姆斯瘤 (WT) 中表现有前途. 这种抗血管生成疗法表现出良好的耐受性和有效性,为患者提供了潜在的桥梁治疗.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 血管新生对于瘤的进展和转移至关重要.
- 贝瓦西祖马布是一种抗血管原剂,用于各种固体瘤.
- 贝瓦西祖马布在预后不佳的威尔姆斯瘤 (WT) 的疗效尚未得到充分证实.
研究的目的:
- 审查含有贝瓦西祖马布的疗法在复发性或耐火性WT的疗效.
- 评估贝瓦齐祖马布在这个患者群体中的耐受性和安全性.
主要方法:
- 在PubMed,Scopus和ClinicalTrials.gov数据库中进行文献搜索.
- 包括2007年至2020年间发表的八篇论文.
- 对治疗方案的分析,主要是温克里斯,义利诺坦和贝瓦西祖马布 (VIB) ±泰莫索洛米德 (VITB).
主要成果:
- 在16名可评估患者中有56%的客观反应 (OR) 被观察到.
- 在89% (8/9) 的患者中,VIB/VITB疗法实现了OR或稳定疾病 (SD).
- 贝瓦西祖马布一般耐受性良好,常见的毒性包括高血压和蛋白尿.
结论:
- 当bevacizumab在组合疗法中使用时,它在复发性/耐药性WT中显示出潜在的有效性和良好的耐受性.
- 这些组合可以作为通往其他治疗方法的桥梁.
- 需要进一步的有针对性的试验来证实这些发现,并探索个性化的治疗选择.
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