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Updated: Jun 20, 2025

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
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Published on: September 29, 2011

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整个Saccharomyces cerevisiae基因组的不稳定性是由于Pms1内核酶缺乏导致的

Scott A Lujan1, Marta A Garbacz1,2, Sascha E Liberti3

  • 1Genome Integrity & Structural Biology Laboratory, NIH/NIEHS, DHHS, Research Triangle Park, NC 27709, USA.

Nucleic acids research
|July 17, 2024
PubMed
概括

Pms1的内核酶活性对于DNA不匹配修复 (MMR) 是至关重要的. 它的损失显著增加了突变率,突显了它在维持基因组稳定性和预防癌症方面的重要性.

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