在急性心肌梗塞整合癌症数据后出血风险预测:更新的PRECISE-DAPT癌症评分
Mohamed Dafaalla1, Francesco Costa2, Evangelos Kontopantelis3
1Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele Rd, Stoke-on-Trent ST5 5BG, UK.
European heart journal
|July 17, 2024
概括
将癌症添加到PRECISE-DAPT得分中,可以提高其在预测ST升高心肌梗塞患者大出血风险方面的准确性. 修改后的分数可以更好地识别癌症患者的高出血风险,而不会影响没有癌症的人的表现.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 临床风险预测预测
背景情况:
- PRECISE-DAPT评分用于预测ST升高心肌梗塞 (STEMI) 患者的出血风险.
- 癌症是一种重要的并发症,可能会影响STEMI患者的出血风险.
研究的目的:
- 评估将癌症诊断纳入作为预测器对PRECISE-DAPT得分的表现的影响.
- 评估是否添加癌症可以提高STEMI患者出血风险分层的准确性.
主要方法:
- 分析了来自英国注册 (2005-2019) 的STEMI患者的国家队列 (n=216,709).
- 通过添加癌症作为二进制变量,创建了一个修改后的PRECISE-DAPT得分.
- 使用考克斯回归和C统计学,将修改后得分的表现与原始得分进行了比较.
主要成果:
- 修改后的分数显示,与原来的分数 (C-统计数据0.60) 相比,歧视程度略高 (C-统计数据0.64).
- 在癌症患者中,修改后的得分将94.0%重新归类为高出血风险 (HBR),而原始得分为65.5%.
- 在没有癌症的患者中,修改后的得分保持了表现 (C统计值0.63).
结论:
- 将癌症纳入PRECISE-DAPT得分可以显著改善出血风险预测,特别是在癌症患者中.
- 修改后的分数有效地将大多数癌症患者识别为HBR,增强了临床决策.
- 增强的得分保持了它在非癌症STEMI患者的预测能力.
更多相关视频
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
3.4K
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
5.3K
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
133
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
133
01:21Cancer Survival Analysis
336
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
336