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Updated: Jun 20, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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通过RP-HPLC估计CDK抑制剂:用于与PPI的药理学相互作用研究的应用

Mrunal Pradeep Desai1, Prajakta Harish Patil1, Gurupur Gautham Shenoy1

  • 1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

Bioanalysis
|July 17, 2024
PubMed
概括

质子抑制剂 (PPI) 显著改变了palbociclib和ribociclib的药理动力学. 这种相互作用需要仔细考虑最佳的癌症化疗方案.

关键词:
在 CYP3A4 中.循环林依赖的激酶抑制剂药物 药物相互作用多种药房多种药房质子抑制剂的使用

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Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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