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Updated: Jun 20, 2025

DNA-magnetic Particle Binding Analysis by Dynamic and Electrophoretic Light Scattering
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DNA-magnetic Particle Binding Analysis by Dynamic and Electrophoretic Light Scattering

Published on: November 9, 2017

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结合剂响应的DNA链位移使小分子DNA结合剂的高通量和高保真性发现成为可能

Junpeng Xu1,2,3, Hui Deng4, Lang Wu1

  • 1Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.

Analytical chemistry
|July 17, 2024
PubMed
概括

我们开发了一种新的检测方法,用于使用结合剂响应脚介导的DNA链位移 (BR-TMSD) 寻找DNA结合分子. 这种方法成功地从一千多种化合物中识别出了19种新型DNA结合剂.

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Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage

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Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level10:11

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

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Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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