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西班牙儿童对花生和树木坚果的耐受性,他们对脂质转移蛋白质的敏感性是独有的

Isamar De Agrela-Mendes¹, María Pedrosa¹, Carmen Gómez-Traseira^1,2

¹Department of Allergy, La Paz University Hospital, Madrid, Spain.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

|July 17, 2024

概括

患有脂质转移蛋白 (LTP) 敏感性的儿童通常可以耐受花生,子和核桃. 这项研究建议进行个性化测试,以避免不必要的坚果避免饮食.

科学领域:

食物过敏研究食物过敏研究
临床免疫学临床免疫学
儿科过敏症儿童过敏症

背景情况:

在西班牙,花生和树木坚果过敏很普遍,脂质转移蛋白 (LTP) 是常见的过敏原.
低TP敏感性经常导致多种食物敏感性,导致限制性饮食和降低生活质量.
研究LTP敏感儿童的坚果耐受性可以帮助减轻饮食负担.

研究的目的:

评估对LTP敏感的儿童对花生,子和核桃的耐受性.
为了确定这些孩子是否可以安全地食用坚果,从而避免过于严格的饮食.

主要方法:

对被诊断患有花生,子或核桃过敏的人进行前性研究.
过敏学评估包括皮肤刺伤测试和坚果和分子组件的IgE测量.
开放口服坚果挑战,参与者具有LTP敏感,但没有种子储存蛋白敏感.

主要成果:

包括75个对花生,44个对子和51个对核桃过敏的人.
观察到的高耐受率:花生98.6%,子97.72%,核桃84.3%.
所有参与者都接受了口服坚果挑战,使用可疑的过敏原.

结论:

大多数患有LTP敏感性且对种子储存蛋白没有IgE反应性的患者可以耐受花生,子和核桃.
个性化的坚果耐受性评估对于防止不必要的饮食限制至关重要.
研究结果支持一种更个性化的方法来管理坚果过敏.

关键词:

食物过敏食物过敏子过敏子过敏脂肪转移蛋白质的转移蛋白质是什么口服食物挑战口服食物挑战对于花生过敏的过敏树木坚果过敏树木坚果过敏核桃过敏是一种过敏.

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