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人类乳头瘤病毒和早产之间的关联:系统性审查和元分析

Dénes Kovács^1,2, Anett Szabó^2,3, Péter Hegyi^4,5

¹Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.

Acta obstetricia et gynecologica Scandinavica

|July 17, 2024

概括

这项元分析发现,人类乳头瘤病毒 (HPV) 感染与孕妇早产之间存在联系. 需要进一步的研究来探索这种关联及其对产科的影响.

科学领域:

产科和妇科产科和妇科
传染性疾病传染性疾病
泌尿生殖系统医学

背景情况:

人类乳头瘤病毒 (HPV) 感染是最常见的性传播感染,估计有80%的人一生患病率.
虽然已知有瘤相关性,但HPV与不良妊娠结果的关联是有争议的,之前的研究偏为使用巴氏涂抹检测HPV.
这一元分析的重点是基因确认的HPVDNA测试,以准确评估其对妊娠并发症的影响.

研究的目的:

评估基因确认的人类乳头瘤病毒 (HPV) 感染与不良妊娠结果之间的关联.
为了解决先前的元分析中的偏见,仅包括使用HPV DNA测试的研究.

主要方法:

对队列,横截面和病例控制研究进行了系统的元分析,搜索了PubMed,Embase和CENTRAL.
符合条件的研究包括检测HPVDNA的孕妇.
分析了涉及7008名女性的14篇文章的数据,计算了95%置信区间 (CI) 的几率比率 (OR),并对高风险HPV和HPV16/18菌株进行亚组分析.

主要成果:

在早产和HPV感染之间观察到显著的关联 (OR: 1.94,CI: 1.31-2.87).
在高风险HPV (OR: 1.94,CI: 0.82-4.59) 或HPV 16/18感染女性 (OR: 2.08,CI: 0.50-8.63) 的子组中,没有发现过早分娩的显著关联.
在HPV感染和自发流产之间没有发现显著的关联 (OR:1.02,CI:0.16-6.31).

结论:

分析表明,人类乳头瘤病毒 (HPV) 感染和早产之间存在显著的关联.
综合考虑混变量对于未来对HPV和怀孕结果的研究至关重要.
全球HPV疫苗接种计划对于瘤学和产科都至关重要.

关键词:

感染HPV病毒的感染.怀孕怀孕怀孕怀孕怀孕怀孕期间的损失怀孕期间的损失过早分娩过早分娩是什么性传播感染性传播感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性

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