在肺高血压模型中,通过施用甲状腺激素和葡萄汁改善右心室功能和氧化应激
Isabel Proença1, Patrick Turck1, Vanessa Ortiz1
1Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil.
Arquivos brasileiros de cardiologia
|July 17, 2024
概括
葡萄汁和甲状腺激素通过减少氧化应激和改善心脏功能来治疗肺动脉高血压 (PAH) 是有前途的. 这些治疗提供心脏保护,并可能有助于管理PAH患者的RV重塑.
科学领域:
- 心血管研究研究心血管研究
- 肺高血压是什么意思 肺高血压
- 氧化压力生物学 氧化压力生物学
背景情况:
- 肺动脉高血压 (PAH) 导致右心室 (RV) 逆转型和心力衰竭.
- 目前的治疗方法缺乏针对PAH的不适应性RV重塑的具体干预措施.
- 氧化应激和改变的处理与PAH病变产生有关.
研究的目的:
- 研究葡萄汁 (GJ) 和甲状腺激素 (TH) 对PAH诱导的氧化应激的治疗作用.
- 在PAH模型中评估GJ和TH对心脏功能变化的影响.
- 探索GJ和TH在减轻PAH影响中的潜在生化机制.
主要方法:
- 心声学参数评估了肺血管阻力 (AT/ET比率),RV收缩性 (TAPSE) 和RV透静功能 (E/A峰值比率).
- 评估的总活性氧物种 (ROS),脂质过氧化 (TBARS),抗氧化酶,处理蛋白和亲氧化剂/抗氧化剂蛋白表达.
- 使用p<0.05.05来确定统计学意义.
主要成果:
- 无论是GJ和TH治疗都降低了肺抵抗 (~22%) 和改善了RV收缩性 (TAPSE ~11%) 和AT/ET比率 (~26%).
- GJ和TH降低了山丁氧化酶水平 (~49%) 并使HSP70和处理蛋白表达正常化.
- 单独对TH治疗改善了透缩功能 (~ 50%),并增加了NRF2免疫不满足 (~ 48%).
结论:
- 这项研究首次证明,在PAH模型中,联合TH和GJ的管理改善了PAH模型中的功能和生物化学.
- GJ和TH都通过调节氧化应激和处理的蛋白质来产生心脏保护作用.
- 这些发现表明GJ和TH在管理PAH和相关心脏功能障碍方面具有新的治疗潜力.
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