血清肌态素与健康青少年的中心至外围动脉硬度梯度有关:MACISTE研究
R Curcio1, L Nunziangeli2, E Nulli Migliola1
1Unit of Internal Medicine, Azienda Ospedaliera "Santa Maria", Terni, Italy.
American journal of hypertension
|July 17, 2024
概括
血清肌静素 (sMSTN) 水平与青少年的动脉硬有关. 更高的sMSTN与脉冲波比 (PWVr) 的增加有关,这表明动脉硬度的梯度.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 肌态素是一种与TGF-β相关的蛋白质,调节肌肉生长和细胞外基质.
- 它对血管光滑肌肉细胞具有益菌性和抗缩性作用.
研究的目的:
- 为了研究血清肌静止素水平 (sMSTN) 和动脉硬度测量 (cf-PWV,cr-PWV,PWVr) 之间的关联.
- 在一组健康的青少年中探索这些关联.
主要方法:
- 分析了来自MACISTE研究的128名健康青少年 (平均年龄17岁).
- 使用ELISA测量血清肌肉静态素 (sMSTN).
- 脉冲波速度 (PWVs) 使用平面化度测量进行了评估.
主要成果:
- 脉冲波比 (PWVr) 在sMSTN四分位数中呈现线性增加 (P为趋势=0.03).
- 单独与cf-PWV和cr-PWV的相关性并不显著.
- sMSTN与HDL胆固醇正相关,与LDL胆固醇负相关.
- PWVr-sMSTN关联独立于年龄,性别,BMI和其他心血管风险因素.
结论:
- 血清肌态素 (sMSTN) 与PWVr独立相关,PWVr是中至外围动脉硬的标志物.
- 在青少年中,肌静止素可能会对动脉壁的特性产生不同的影响.
相关概念视频
Assessing Blood pressure in the Leg
2.3K
Proper measurement of leg blood pressure is a critical skill for healthcare providers, ensuring precise and reliable readings. When performed correctly, this procedure informs patient care and enhances the efficacy of interventions. The following text outlines step-by-step guidelines to measure blood pressure in the leg, providing clarity and ease of understanding for practitioners.
Preparation:
Preparation:
2.3K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
73
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
73
Hormonal Regulation of Blood Pressure
2.6K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.6K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
133
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
133
Assessment of blood pressure in brachial artery(two-step method)
678
Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
678
Hypertension and Regulation of Blood Pressure
2.0K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.0K


