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Updated: Jul 8, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

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基于mRNA的HIV-1疫苗

Shamim Ahmed1, Alon Herschhorn1,2,3,4,5,6,7

  • 1Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Clinical microbiology reviews
|July 17, 2024
PubMed
概括

针对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 取得成功的信使RNA (mRNA) 疫苗,目前正在针对人类免疫缺陷病毒1型 (HIV-1) 开发. 这些新的HIV-1 mRNA疫苗正在临床前和临床试验中,以克服免疫逃避挑战.

关键词:
艾滋病病毒-1 艾滋病病毒-1包裹中的葡萄糖蛋白质.在mRNA疫苗的使用中.

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Overview
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Microorganisms in Medicine and Therapeutics

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Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
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Vaccines

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