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人类胎盘的建模:在发育和生殖毒理学的体外应用

Sarah Park^1,2, Edward Sidney Hunter²

¹Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN, USA.

Critical reviews in toxicology

|July 17, 2024

概括

胎盘对于发育至关重要,但它在毒理反应中的作用还未得到充分研究. 本综述探讨了早期的胎盘发育和体外模型,以了解子宫内环境暴露的影响.

科学领域:

生殖生物学生殖生物学
发展性毒理学发展性毒理学
环境健康环境健康

背景情况:

胎盘对于产前和产后发育至关重要,它执行专门的功能.
在子宫内暴露的化学物质可以显著影响胎盘组织和父母和后代的长期健康.
胎盘在胚胎/胎儿发育中的毒理重要性和功能尚未得到充分研究.

研究的目的:

审查人类早期的胎盘发育.
要突出用于研究胎盘发育的体外模型.
了解胎盘过程中的发育毒性从子宫内环境暴露.

主要方法:

关于胎盘早期发育的文献综述.
对现有和潜在的体外模型的调查.
与发育毒性相关的胎盘功能分析.

主要成果:

胎盘的早期发育是复杂的,对胎儿生长至关重要.
在体外模型为研究胎盘对毒素的反应提供了有价值的工具.
特定的模型可以阐明发育性毒性的机制.

结论:

对胎盘毒理学的进一步研究是必不可少的.
在体外模型是促进了解怀孕期间环境暴露的关键.
保护胎盘功能对于后代的健康至关重要.

关键词:

在DART中使用DART.在体外 (in vitro) 的情况下.这些是NAMs.在子宫内,在子宫内.胎盘胎盘胎盘胎盘怀孕怀孕怀孕怀孕怀孕

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