在COVID-19后的神经心理功能:在SARS-CoV-2感染后有或没有持续投诉的个体之间存在微小的差异
Anouk Verveen1,2, Sander C J Verfaillie1,3,4,5, Denise Visser3,4
1Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
The Clinical neuropsychologist
|July 17, 2024
概括
在SARS-CoV-2感染 (COVID-19) 后,持续的严重疲劳和难以集中注意力通常与客观认知障碍无关,这项研究在广泛的神经心理测试中发现.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 认知心理学 认知心理学
背景情况:
- 自我报告的严重疲劳和难以集中注意力是SARS-CoV-2感染后常见的持续性投诉.
- 这些主观症状与客观神经心理功能之间的关系尚不清楚.
- 了解这种关系对于诊断和管理长期COVID认知缺陷至关重要.
研究的目的:
- 为了在SARS-CoV-2感染后比较持久严重疲劳和难以集中注意力的个体中的客观神经心理功能.
- 为了确定受这些持续的COVID-19后症状影响的特定认知领域.
主要方法:
- 评估了在SARS-CoV-2感染后至少3个月的持续严重疲劳 (检查单个力量 (CIS) 疲劳≥35) 和难以集中精力 (CIS度≥18) 的人群.
- 综合的神经心理测试涵盖了整体认知,注意力,处理速度,执行功能,记忆,视觉构建和语言 (18项测试).
- 认知障碍被定义为T-score ≤ 35 (1.5 SD低于规范数据).
主要成果:
- 在230名参与者中,111人报告了持续的投诉,97人没有. 评估发生在感染后23个月的中位数.
- 持久抱怨的个体显示,信息处理速度较慢的可能性更高 (Stroop字读,OR=2.45).
- 持久性投诉与特定测试 (D2 CP,TMT B,TMT B下载A) 的分数较低有关,但与其他认知领域无关.
结论:
- 在COVID-19后的主观严重疲劳和难以集中注意力通常与广泛的认知障碍无关,在详细的神经心理测试中.
- 虽然处理速度和执行功能的某些特定缺陷可能存在,但广泛的认知障碍不是常态.
- 需要进一步的研究来了解持续的主观症状背后的机制及其有限的客观认知相关性.
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