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在结肠直肠癌中通过Ca过载/ER压力/STING/IRF3途径激活Caspase-1诱导的 Pyroptosis,用于Condroitin硫酸盐修饰的Hydroxyapatite

Qing Chen^1,2, Bin Peng³, Lifan Lin²

¹Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, 314001, China.

Small (Weinheim an der Bergstrasse, Germany)

|July 17, 2024

概括

新的纳米粒子将"冷"的结直肠瘤转化为"热"的瘤,提高免疫治疗的有效性. 氏丁硫酸盐-氧酸盐-凯姆菲罗尔纳米颗粒诱导热,使瘤更容易对治疗做出反应.

科学领域:

生物医学工程生物医学工程
纳米医学是一种纳米医学.
癌症治疗癌症治疗

背景情况:

免疫检查点抑制剂 (ICI) 是一种关键的结肠直肠癌 (CRC) 治疗方法,但仅有利于免疫激活 ("热") 瘤 (≈5%).
热,一种被编程的细胞死亡,可以将免疫抑制性 ("冷") 瘤转化为免疫性 ("热") 瘤.
现有的释放的酸纳米颗粒 (NP) 在瘤向和释放方面存在局限性.

研究的目的:

开发新型纳米粒子,用于CRC中向激素灭亡的诱导.
通过改变瘤微环境 (TME) 来提高免疫检查点抑制剂的疗效.

主要方法:

氏丁硫酸盐 (CS) 用于对CD44受体进行向.
费醇 (KAE) 被纳入作为一种 (Ca) 恒温破坏剂.
CS-HAP@KAE NPs在CRC细胞中进行了合成和特征化,以诱导红细胞灭亡.

主要成果:

CS-HAP@KAE NPs在酸性TME中表现出增强的瘤细胞结合和Ca释放.
这些NP诱导了细胞内Ca过载,导致CRC细胞中的热亡.
该过程通过内质网膜应激激活了STING/IRF3通路,将TME从"冷"转换为"热".

结论:

CS-HAP@KAE NPs有效地诱导热和重编程TME.
这种纳米医学方法有望提高ICI在结直肠癌中的疗效.
向性热致死提供了一种策略,以克服感冒瘤对免疫治疗的抵抗力.

关键词:

刺痛是一种刺痛.过多的负荷导致过载.结肠直肠癌是什么意思热致灭 (pyroptosis) 是一种致的过程.瘤免疫疗法免疫疗法

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