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在非编码RNA作为阻塞性睡眠呼吸暂停低通风综合征的生物标志物的进展

Jingli Li¹, Limei Sun², Yuan Zhao³

¹Kunming University of Science and Technology Affiliated The First People's Hospital of Yunnan Province, Kunming, 650500, Yunnan, China.

Sleep & breathing = Schlaf & Atmung

|July 17, 2024

概括

非编码RNAs (ncRNAs) 显示为用于诊断阻塞性睡眠呼吸暂停低通风综合征 (OSAHS) 和相关疾病的生物标志物. 对ncRNA表达的进一步研究可能会导致早期检测和改善OSAHS的治疗策略.

科学领域:

生物化学生化学
遗传学是一个遗传学.
睡眠医学睡眠医学

背景情况:

阻塞性睡眠呼吸暂停低通风综合征 (OSAHS) 是一种普遍的疾病,与许多系统性健康问题有关,包括心血管疾病,糖尿病和认知功能障碍.
非编码RNAs (ncRNAs) 越来越多地被认为是它们在各种医疗条件下作为新生物标志物的潜力.

研究的目的:

审查目前关于ncRNAs在OSAHS诊断和管理中的作用和潜力的研究.
探索ncRNAs作为OSAHS及其相关并发症的生物标志物.

主要方法:

在包括PubMed和Web of Science在内的数据库中进行系统的文献搜索.
用于检索的关键词包括"OSAHS"",ncRNA"",lncRNA"",miRNA"和"circRNA".

主要成果:

循环的ncRNAs显示出OSAHS的显著诊断准确性,有可能用于查工具.
在OSAHS患者中ncRNAs的差异表达可以预测疾病的严重程度和对CPAP等疗法的反应.
血清ncRNAs在诊断高血压,阿尔茨海默病和动脉样硬化等OSAHS并发症方面具有实用性.

结论:

在OSAHS患者中ncRNA表达变化代表了新型诊断和治疗生物标志物的有希望的途径.
ncRNAs可以作为OSAHS并发症的生物标志物,包括糖尿病,心血管,呼吸道和认知障碍.
预计ncRNA研究的进步将提高OSAHS及其并发症的早期检测,诊断和治疗.

关键词:

生物标志物生物标志物复杂化复杂化复杂化复杂化诊断诊断诊断诊断诊断没有编码的RNA.阻塞性睡眠呼吸暂停低呼吸暂停综合征

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