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菌根疗法:一种替代性治疗方式,用于MDR细菌感染

Namrata Pal^1,2, Poonam Sharma¹, Manoj Kumawat¹

¹Department of Microbiology, ICMR-National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh, India.

Infectious diseases (London, England)

|July 17, 2024

概括

菌体疗法为对抗多药耐药细菌感染提供了一个有希望的解决方案,特别是对抗ESKAPEE病原体. 持续的研究和监管工作对于其对抗这些关键威胁的临床应用至关重要.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
生物技术是生物技术.

背景情况:

全球越来越多的多药耐药 (MDR) 细菌感染的发病率构成了严重的公共卫生威胁.
逃生病原体 (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., Escherichia coli) 是导致高耐药性医院获得的感染的主要原因.
抗生素疗效的下降需要开发新的抗菌战略.

研究的目的:

审查针对多药耐药细菌感染的菌体治疗 (PT) 的临床研究.
探索菌体治疗从实验室研究到临床应用的转化.
突出菌体及其蛋白质在临床前和临床发展方面的进展.

主要方法:

关于菌体治疗现有临床研究的全面审查.
对菌体疗效和应用的临床前和临床研究的审查.
分析菌素疗法开发和实施中的挑战和机遇.

主要成果:

菌体疗法正在成为抗生素对抗MDR病原体的可行替代品.
菌体及其蛋白质显示出单独或与抗生素结合使用的潜力.
临床前和临床研究的进步正在为菌体治疗的应用铺平道路.

结论:

菌体治疗代表了对抗MDR细菌感染的有希望的策略.
建立安全和经批准的菌体给药路线对于患者的安全至关重要.
持续的研究,创新和监管监督对于实现菌体治疗的全部临床潜力至关重要.

关键词:

菌体疗法是一种菌体疗法.抗微生物耐药性抗微生物耐药性菌体尾酒是一种菌体尾酒.菌体的耐药性菌体的耐药性菌体-抗生素协同作用

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