用环境和生活方式因素对3大青年群体的自杀企图风险进行分类
Elina Visoki1,2, Tyler M Moore2,3, Xinhe Zhang4
1Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania.
JAMA psychiatry
|July 17, 2024
概括
环境和生活方式因素在很大程度上预测了青少年的自杀企图. 综合这些因素的暴露性评分为不同人群提供了可通用的风险分类方法,改善了临床翻译.
科学领域:
- 环境健康 环境健康
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 自杀是青少年死亡的主要原因.
- 环境和生活方式因素影响自杀行为,但对于风险评估来说,很难量化.
- 目前的风险评估方法缺乏这些因素的可复制性和临床转化.
研究的目的:
- 量化环境和生活方式因素对青少年自杀企图风险分类的总体贡献.
- 开发和验证一个可概括的自杀企图风险暴露性评分.
主要方法:
- 一个队列研究,利用三种不同的青年样本 (美国国民,英国国民,美国儿科临床) 的暴露全组关联研究 (ExWAS).
- 确定风险和保护性环境/生活方式因素,并计算汇总的暴露性评分.
- 后勤回归模型被用来评估在独立数据集中暴露性得分与自杀企图的关联.
主要成果:
- 开发了99个重要的风险和保护因素的曝光学评分.
- 这一分数与所有三组的自杀企图有显著的关联,这解释了传统风险因素之外的大量差异 (17.6%-22.6%).
- 暴露性评分最高五分之一的年轻人表现出自杀企图的几率明显更高 (ORs从4.3到5.8).
结论:
- 暴露性得分提供了一种可通用和有效的方法来分类年轻人自杀企图风险.
- 这种方法可以在不同的临床和人口环境中应用.
- 研究结果支持对环境和生活方式因素评估的临床转化,以预防青少年自杀.
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