危急病患者蛋白质摄入量与功能能力之间的关联:一项回顾性队列研究
Fábio Araújo1, Juan G Posadas-Calleja2, Maitreyi Raman3
1Department of Nutrition Services, Alberta Health Services, Calgary, Alberta, Canada.
JPEN. Journal of parenteral and enteral nutrition
|July 17, 2024
概括
在重症监护室 (ICU) 摄入较高的蛋白质 (1.2-1.5 g/kg/day) 改善了患者在出院时的功能能力 (CPAx). 这种最佳的蛋白质剂量增强了恢复,无论能量摄入量或营养状况如何.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 康复医学 康复医学 康复医学
背景情况:
- 重症监护室 (ICU) 的蛋白质建议侧重于死亡率和发病率.
- 蛋白质摄入量对ICU幸存者的功能恢复的影响尚不清楚.
研究的目的:
- 评估不同蛋白质剂量与ICU幸存者的功能能力之间的关联.
- 确定最佳的蛋白质摄入量,以支持体力功能康复后ICU.
主要方法:
- 对531名ICU幸存者的回顾性队列研究,停留时间≥7天.
- 患者被分为低 (<0.8),中等 (0.8-1.19),高 (1.2-1.5) 和非常高 (>1.5) 蛋白质摄入量组 (g/kg/day).
- 功能能力以切尔西物理评估得分 (CPAx) 测量,在ICU释放时,对混因子进行调整.
主要成果:
- 高蛋白剂量 (1.2-1.5 g/kg/day) 与在ICU出院时显著更高的CPAx得分有关.
- 这一关联在调整年龄,疾病严重程度和通风持续时间后仍然显著.
- 能量摄入量和营养状况没有改变蛋白质剂量对功能能力的影响.
结论:
- 每天1.2-1.5g/kg的蛋白质摄入量与ICU幸存者的优越功能能力有关.
- 这种蛋白质剂量似乎是促进身体恢复的关键因素,独立于能量摄入量或营养状况.
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