怀孕期间的疟疾:婴儿步骤
Stephen J Rogerson1,2, Elizabeth H Aitken1,3
1Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne.
Current opinion in infectious diseases
|July 17, 2024
概括
怀孕期间的疟疾构成重大威胁,特别是在非洲,对治疗和诊断挑战的耐药性日益增加. 新的战略正在出现,但有效预防和控制的障碍仍然存在.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 全球健康 全球健康
背景情况:
- 孕期疟疾不成比例地影响孕妇和婴儿,特别是在非洲,风险增加了.
- 亚微观疟疾感染越来越多地被认可,但难以检测,它们对疾病和传播的影响仍然不清楚.
- 目前的治疗指南面临的挑战是晚期产前诊所出诊和药物耐药性.
研究的目的:
- 审查当前怀孕期间疟疾的情况,重点关注挑战和最近的进展.
- 突出疟疾对怀孕结果的影响以及治疗和预防的复杂性.
- 讨论孕妇人口疟疾预防和控制的新兴策略.
主要方法:
- 关于怀孕期间疟疾的最新科学文献的审查.
- 对疟疾风险和治疗疗效趋势的分析.
- 检查胎盘疟疾和疫苗开发的生物机制.
主要成果:
- 全球降低了孕妇疟疾风险,除了非洲,疟疾风险已经上升.
- 建议在第一季度治疗阿尔特梅瑟-卢梅方特林,但晚期呈现是常见的.
- 硫素-甲胺耐药性正在增加,像二甲素-皮佩拉奎因这样的替代品在怀孕后果方面显示出混合的结果.
- 疟疾会对胎盘发育和胎儿生长产生负面影响,导致孕期婴儿的体型较小.
结论:
- 尽管了解和潜在的新干预措施取得了进展,但在怀孕期间控制疟疾方面仍然存在重大障碍.
- 对治疗方法的非疟疾效应和针对VAR2CSA蛋白的疫苗开发的进一步研究显示出有希望.
- 对改善预防和控制的乐观看法是合理的,但为了克服现有的挑战,必须继续努力.
更多相关视频
10:22Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
8.9K
09:13Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
Published on: November 22, 2024
1.3K
相关概念视频
00:58Symbiosis
27.7K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
27.7K
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K