根据种族和种族分类乳腺癌亚型的风险因素:范围审查
Amber N Hurson1, Thomas U Ahearn1, Hela Koka1
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Journal of the National Cancer Institute
|July 17, 2024
概括
乳腺癌风险因素显示由雌激素受体 (ER) 状态的差异,在种族群体之间一致. 然而,需要在不同人群中进行更多的研究,以了解乳腺癌异质性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 乳腺癌包括不同的分子亚型.
- 雌激素受体 (ER) 状态显著影响乳腺癌风险因素.
- 有限的评估存在于这些协会在不同的种族和民族群体的一致性.
研究的目的:
- 调查18种乳腺癌风险因素与ER定义的亚型之间的关联的一致性.
- 为了评估这些协会在女性识别为亚裔,黑人或非洲裔美国人,西班牙裔或拉丁裔或白人.
- 通过跨种族和种族群体的ER状态来确定乳腺癌病因异质性的程度.
主要方法:
- 进行了定性,范围的文献综述 (1990-2022年).
- 使用系统性审查的首选报告项目和范围审查的元分析扩展 (PRISMA-ScR).
- 根据专家的共识,确定病因异质性的证据 (有说服力,有暗示性,不存在或不确定的).
主要成果:
- 平等性,第一次出生时的年龄,绝经后的BMI,口服避孕药的使用和绝经期的激素治疗显示出最强有力的病因异质性的证据.
- 调查结果在种族和种族群体中普遍一致,尽管证据的强度有所不同.
- 白人女性的出版物最为丰富,其次是亚洲,黑人或非裔美国人,西班牙裔或拉丁裔女性.
结论:
- 已确定的乳腺癌风险因素根据ER状态表现出病因异质性,在种族和种族群体之间一致.
- 对非白人群体的证据有限,这突出了关键的研究缺口.
- 对于全面了解乳腺癌病因异质性而言,不同人群中较大,可比较的数据集至关重要.
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