形光受体的分化受甲状腺激素载体MCT8在视网膜色素表皮中的调节
1Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
概括
甲状腺激素通过MCT8在视网膜色素表皮中的运输对形光感受器的发展和色彩视觉至关重要. 这个传送器调节型的身份和功能,影响视觉感知.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 细胞生物学 细胞生物学
背景情况:
- 甲状腺激素信号传递对光受体成熟和色彩视觉至关重要.
- 甲状腺激素到达由血液视网膜屏障保护的形光受体的机制尚未完全理解.
研究的目的:
- 研究甲状腺激素运输在光受体差异化和功能中的作用.
- 为了确定特定的细胞类型和分子机制,涉及到输送甲状腺激素到.
主要方法:
- 在小鼠中利用遗传方法,包括基因缺陷和组织特异性切除/再表达模型.
- 分析了形光受体基因表达,形类型识别 (M和S形) 和电网红图反应.
- 专注于视网膜色素上皮 (RPE) 作为血液视网膜屏障的关键组成部分.
主要成果:
- 甲状腺激素膜载体MCT8 (SLC16A2) 在RPE表达,并调节区分.
- 缺乏Mct8的小鼠表现出改变的基因表达,受损的电网红图反应,以及从中长 (M) 波长到短 (S) 波长的标识的转变.
- 特定于RPE的MCT8功能的删除或恢复直接影响标识和甲状腺激素信号,表明对膜的控制.
结论:
- RPE在通过MCT8.8调解甲状腺激素向光受体发送信号方面发挥着关键作用.
- 这种依赖于RPE的甲状腺激素运输对于建立和维持M标识和整体介导色彩视觉至关重要.
- 这些发现揭示了RPE对视觉内分泌调节的新途径,将其已知的功能扩展到溶液运输和平衡之外.
相关概念视频
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Synthesis and Regulation of Thyroid Hormones
4.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
Channel Rhodopsins
2.5K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
2.5K
Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K


